Kane, who has a history of ankle problems, appeared to twist his ankle after getting it caught under a falling Richarlison in the closing stages of Spurs’ 2-2 Premier League draw at Goodison Park on Friday night.
Kane squatted down holding his ankle before receiving treatment, but shook his head and limped off the pitch to be replaced by Dele Alli.
The England striker may now be a doubt for next weekend’s Carabao Cup Final against Manchester City, where Kane will no doubt be pivotal to Jose Mourinho’s hopes of pipping Pep Guardiola to silverware.
Following the game, Mourinho told Sky Sports: “It is too early to say something. For him to leave the pitch with a few minutes to go is obviously because he felt something.
“Let me be optimistic and believe that he has time to recover. Let’s see.
“Let me be optimistic and believe it’s nothing serious. It’s obvious he’s a very important player for us. I cannot say much or speculate.”
Kane’s team-mate Eric Dier added: “Obviously it’s always worrying when you see him limping because he doesn’t fall over easily. He takes a lot of knocks.
“It’s early days to say how bad it is but I’m sure he’s a tough boy so will do what he can to be ready.
“We have to prepare for the cup final as best we can and try to pick up as good results we can to finish strongly. We owe it to ourselves and the fans. It’s about pride.”
England boss Gareth Southgate will also be hoping that the injury is not serious with Kane the focal point of his attack for Euro 2020.
More to follow.