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3 Things You Need to Know Before Taking a Collagen Supplement

·8-min read
3 Things You Need to Know Before Taking a Collagen Supplement

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Quickly and recently, amino acids have become big business. Whether you’re shopping for a collagen supplement, bone broth or even more meat and dairy foods, the different amino acids that make up these proteins are what you’re ultimately buying and ingesting, says Mark Moyad, M.D., director of preventive and alternative medicine at the University of Michigan.

Your body uses amino acids to build muscle, bone, cartilage, skin, hair, connective tissue and much more. There are many different types of amino acids, but the most abundant kind in your body make up collagen. Collagen is the main structural protein that forms your connective tissues and skin.

Since your body’s collagen production declines as you age and you need adequate collagen for strong bones, joints and skin, adding more collagen to your diet sounds like a no-brainer. That’s why many supplement makers have started selling collagen powders and pills, which Dr. Moyad says are made mostly from animal parts, like fish scales or cow bones or skin. (Vegans, take note.)

But do these supplements really do anything? Here’s what you need to know.

What is collagen powder?

According to Rahul Shah, a board-certified orthopedic spine and neck surgeon at Premier Orthopaedic Spine Associates, there are many types of collagen, each composed of different "peptides" or amino acids. Different types form skin and tendons as opposed to cartilage. Figuring out which ones may help your health has proved tricky. (More on that in a minute.) Also: According to nutritionists from Harvard University, supplements containing collagen are not regulated by the Food and Drug Administration (FDA) and vary a ton.

Most collagen peptides powder on the market contain a "hydrolyzed" type-I collagen extracted from hides, bones, or fish scales. Hydrolyzed simply means that the amino acid chains have been broken down into smaller units, a process that allows the powder to dissolve in both hot and cold liquids.

This type of collagen has become incredibly popular due to the fact you to add it to everything from hot coffee and soups to cold brew and smoothies. It also packs a protein punch, with a two-scoop serving of most collagen peptides delivering around 18 grams.

What are the benefits of collagen powder?

The research on the side effects and potential benefits of collagen supplements is ongoing, but here's what we know right now about the potential upsides for different body parts.


Right now, the most-complete research focuses on joint health. Going back to at least the early '90s, studies have linked collagen supplementation with reduced symptoms of arthritis. Four out of five osteoarthritis sufferers who took a daily 40 mg dose of undenatured type-II collagen saw their pain drop by an average of 26%, according to a 2009 study in the International Journal of Medical Sciences. (Type-II collagen is derived from chicken cartilage — not cow bones and hides or fish scales.)

What’s not clear is how the collagen in the supplement actually helped the OA sufferers’ joints. Rather than contributing to the body’s supply of collagen or cartilage, these supplements may reduce inflammation and consequently improve OA symptoms, the study authors write.

In other words, collagen supplements do not help you rebuild collagen after it's been damage from injury and wear and tear, or even reverse it's natural depletion as you age, says Dr. Shah.

"The science demonstrates that the collagen that is ingested orally is broken down into its building blocks in the digestive process and does not go directly to improving the joints. Injected collagen, on the other hand, seems to work by decreasing overall inflammation when it is injected into the joints but does not clearly rebuild depleted or damaged collagen in joints," he says. But, "joint pain can be somewhat addressed by collagen" by reducing inflammation.

You may want to skip out on those expensive collagen supplements, though since your classic OTC anti-inflammatories (like ibuprofen) are more likely to be effective, says Dr. Shah.


In one study of postmenopausal women, those who took a daily collagen supplement showed improvements in their bone mineral density a year later, especially when they took it in combination with Vitamin D and calcium. The researchers aren't exactly sure why collagen seems to strengthen our skeleton, but they think it might trigger certain anabolic processes that promote the growth of bones.

Doctors at UPenn Medicine also believe that taking a collagen supplement may be able prevent bone loss. However, other M.D.'s think that supplementation not as effective as some might think.

"When ingested, collagen is broken down by our digestive system into its building blocks," says Dr. Shah. "These building blocks then are used by our bodies in the form of energy [and] are not preferentially used by the body to form bone or any other musculoskeletal tissues."

Skin and Hair

Photo credit: PeopleImages - Getty Images
Photo credit: PeopleImages - Getty Images

Talk to nutrition scientists, and they’ll tell you one of the biggest mistakes they hear when it comes to food and supplements is assuming that something you swallow turns into the same something in your body. That’s not how digestion and biochemistry work.

So do collagen supplements really offer skin and hair benefits? "No way," says Adam Friedman, M.D., an associate professor of dermatology at George Washington University. "The collagen is going to be digested by your GI tract because it isn't built to survive the massive pH changes in the gut."

There’s research to back him up on that. A 2002 study found your gut’s digestive enzymes and acids break down hydrolyzed collagen, which is the type found in most powders. But the same study found type-II collagen may slip through your gut without losing its chemical structure. Of course, we're still learning about the human gut.

More research has linked some collagen peptides to reduced skin wrinkles and healthier skin, so it’s possible some new finding will explain the anecdotal evidence linking collagen powders to nail and hair benefits.

"What we haven't been able to look at is were [the people] who did well in these studies maximizing their own natural collagen intake?" asks Dr. Deirdre Hooper, a board-certified dermatologist at Audubon Dermatology. "Are they eating enough protein in their diet?"

Meaning: There's no evidence that says that taking a collagen supplement is better than eating more collagen-rich foods; there's a chance people benefitted from a collagen supplement simply because they weren't eating enough protein, suggests Hooper.

Also: "The problem is that the studies as far as I can tell have not been done with products that we can buy in the U.S.," says Dr. Hooper. So, any time you buy a collagen supplement you're basically betting on the chance that that product will give your effect you desire.

At this point, there are many more questions than answers regarding collagen supplements and their skin/hair boosting abilities.


There’s some evidence that certain amino acids found in collagen — in particular, one called glycine — may reduce GI inflammation and aid digestion. But again, the evidence is mixed. Most of it didn’t involve collagen powders or supplements, but instead looked at specific amino acids in a lab setting.

Is it safe to take collagen supplements?

Photo credit: Lumina Images - Getty Images
Photo credit: Lumina Images - Getty Images

As is the case with any supplement, the U.S. Food & Drug Administration does not monitor collagen powders for safety or efficacy unless a manufacturer claims its supplement can cure disease, or something goes wrong and people get sick. For this reason, it's important to do a little research before stocking up.

How to choose a collagen supplement:

It's always better to choose food over supplements no matter what, says Jaclyn London, M.S., R.D., C.D.N., author of Dressing on the Side (and Other Diet Myths Debunked). We know tons about the benefits of eating protein (among all other nutrients) in food, but very little about the benefits of eating it in isolated form.

That said, protein isolates can help you meet higher needs due to disease, injury, sports, skin conditions, or appetite loss. It’s crucial to look for the following when buying a collagen supplement:

  1. Choose ones with as few simple ingredients as possible. Collagen protein powder should just be collagen protein isolate, a.k.a. collagen hydrolysate, hydrolyzed collagen, or collagen peptides.

  2. Skip the flavored versions. These can contain added sugars, which could upset your GI tract or just add calories where you didn’t want 'em. Go for the plain version and add a sweetener to desserts yourself.

  3. Look for a third-party certification. Given the lack of FDA regulation, any time you're choosing a dietary supplement, check if a credible group like the NSF, UL, or USP has tested it for safety before.

If you want to try a collagen supplement for two to three months, Dr. Moyad says the health risks should be minimal and there may be some benefits. However, for most of us, as long as you’re eating regular meals and snacks made from a combination of different types of protein (from plants, seafood, or animals), you’re good to go without!

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