Sponsored by eToro
eToro Popular Investor Sharon Connolly, who is one of the most successful female eToro Investors in Australia.
Peru's presidential candidates sought to drum up enthusiasm as the country picked a new leader, with one arriving at a voting station on horseback and others pledging to turn the page on the corruption and mismanagement of recent decades.The election for a new president and Congress comes against the backdrop of a fierce second wave of the coronavirus pandemic and widespread public apathy that has meant none of the 18 candidates has polled more than 13 per cent.
We continue our look at the top 100 prospects in the 2021 NFL draft with No. 26 overall — Bama's mauling center whose medical evaluation will be huge.
Russia's Veronika Kudermetova has won her first WTA title, coming up strong on the big points to beat Montenegro's Danka Kovinic 6-4 6-2 in the Charleston Open final.The 23-year-old Kudermetova did not drop a set in six matches on the way to the championship at the season's first clay court tournament - a feat last accomplished here by Serena Williams in 2012.
Tottenham boss Jose Mourinho claimed he is treated differently from other managers by the media as he hit back at Ole Gunnar Solskjaer's criticism of play-acting by Son Heung-min after Spurs lost 3-1 to Manchester United on Sunday.
Miles Bridges dunked on Clint Capela so hard that he may not actually exist anymore.
Google ran an effort, Project Bernanke, that supposedly gave its ad system an unfair edge — and Texas intends to use this in its antitrust case.
Jose Mourinho has launched a stinging attack on Ole Gunnar Solskjaer after his Manchester United counterpart criticised Son Heung-min following the Red Devils' 3-1 win at Tottenham.Son was involved in a controversial moment in the first half on Sunday when he went down holding his face after being fended off by Scott McTominay in the build-up to an Edinson Cavani goal, which referee Chris Kavanagh eventually ruled out after a VAR intervention.
Stuart Lubbock was found dead in a pool after a party at TV presenter Michael Barrymore’s home in 2001
US recession drama Nomadland, about a community of van dwellers, is the big winner at Britain's BAFTA awards, scooping best film and prizes for its Chinese-born director Chloe Zhao and leading actress Frances McDormand.The British Academy of Film and Television Arts ceremony was held virtually over two nights, with nominees joining in by video, due to the COVID-19 pandemic.
Britain's former prime minister David Cameron, under fire for having sought government help for a finance firm he represented, acknowledged Sunday that he should have gone through formal channels.
This is the year when changes to the retailing landscape become clear, separating retailers that have adapted from those that haven't.
CAMBRIDGE, Mass., April 11, 2021 (GLOBE NEWSWIRE) -- Checkmate Pharmaceuticals, Inc. (NASDAQ: CMPI) (“Checkmate”), a clinical stage biopharmaceutical company focused on developing its proprietary technology to harness the power of the immune system to combat cancer, today announced the presentation of new translational data from Checkmate’s Phase 1b trial of vidutolimod (CMP-001) in combination with pembrolizumab in patients with advanced anti-PD-1 refractory melanoma. Vidutolimod (CMP-001) demonstrates improved response in noninflamed anti–PD-1 refractory melanoma and response is associated with serum CXCL10 (Abstract #: 5231: NCT02680184) During the 2021 AACR Virtual Clinical Trials with Novel Immuno-oncology Strategies Session on April 11 from 4:00 – 5:45pm ET, Jason Luke, MD, Director, Cancer Immunotherapeutics Center, UPMC Hillman Cancer Center, and Associate Professor of Medicine, University of Pittsburgh School of Medicine, presents new translational data from an ongoing Phase 1b study of vidutolimod in combination with pembrolizumab in patients with PD-1 blockade refractory advanced melanoma. Key highlights from these clinical data include: 93% of patients had progressive disease as their last response assessment on prior PD-1 blockade therapy, 42% had an elevated LDH, and the median sum of the target lesions longest diameter was 6.7 cm, indicating advanced diseaseResponse rates to vidutolimod in combination with pembrolizumab were similar across baseline patient characteristics including BRAF mutation, LDH level, number of prior systemic cancer treatments, best response to prior PD-1 blockade therapy, and prior ipilimumabResponders and non-responders were not distinguished by baseline tumor characteristics including PD-L1 CPS, IFNg transcriptional signature, CD8+ T cells, or nonsynonymous mutationsAll patients showed the expected rapid induction of anti-Qb antibodies to the virus-like particle (VLP), which facilitate the pharmacodynamic response to vidutolimod, and the antibody titers were not associated with clinical responseClinical activity of vidutolimod in combination with pembrolizumab was associated with serum CXCL10 induction magnitude, induction of an inflammatory gene expression profile, and CD8+ T cells in injected and noninjected tumors “These translational data provide new insights into the rapid pharmacodynamic responses to vidutolimod and support the conclusion that clinical responses to treatment are not associated with the previously-described predictive markers for response to PD-1 blockade such as inflamed tumors,” said Dr. Jason Luke. About Checkmate Pharmaceuticals Checkmate Pharmaceuticals is a clinical stage biotechnology company focused on developing its proprietary technology to harness the power of the immune system to combat cancer. Checkmate Pharmaceuticals’ product candidate, vidutolimod (CMP-001), is an advanced generation TLR9 agonist delivered as a biologic virus-like particle designed to trigger the body’s innate immune system to attack tumors in combination with other therapies. Information regarding Checkmate Pharmaceuticals is available at www.checkmatepharma.com. Availability of Other Information About Checkmate Pharmaceuticals Investors and others should note that we communicate with our investors and the public using our website (www.checkmatepharma.com), our investor relations website (ir.checkmatepharma.com), and on social media (Twitter and LinkedIn), including but not limited to: investor presentations and investor fact sheets, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that Checkmate Pharmaceuticals posts on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in us to review the information that is posted on these channels, including the investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include additional social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933. Forward Looking Statements Various statements in this release are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including. Words such as, but not limited to, “anticipate,” “believe,” “can,” “could,” “expect,” “estimate,” “design,” “goal,” “intend,” “may,” “might,” “objective,” “plan,” “predict,” “project,” “target,” “likely,” “should,” “will,” and “would,” or the negative of these terms and similar expressions or words, identify forward-looking statements. Forward-looking statements are based upon current expectations that involve risks, changes in circumstances, assumptions and uncertainties. These statements include those regarding our product candidate, including its development and therapeutic potential and the advancement of our clinical and preclinical pipeline; expectations regarding the results and analysis of data; and expectations regarding the timing, initiation, implementation and success of its planned clinical trials for vidutolimod (CMP-001), and the benefits and related implications of current and future partnerships and/or collaborations. Forward-looking statements should not be read as a guarantee of future performance or results and may not be accurate indications of when such performance or results will be achieved. These forward-looking statements are subject to risks and uncertainties, including those related to the development of our product candidate, including any delays in our ongoing or planned preclinical or clinical trials, the results from clinical trials, including the fact that positive results from a trial may not necessarily be predictive of the results of future or ongoing clinical trials, the impact of the ongoing COVID-19 pandemic on our business, operations, clinical supply and plans, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, and obtaining, maintaining and protecting our intellectual property. These and additional risks are discussed in the sections titled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in our Yearly Report on Form 10-K for the full year ended December 31, 2020 dated March 29, 2021, as filed with the Securities and Exchange Commission pursuant to Rule 424(b) under the Securities Act 1933, as amended, which is available on the Securities and Exchange Commission’s website at www.sec.gov, and as well as discussions of potential risks, uncertainties and other important factors in the Company’s subsequent filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and the Company undertakes no duty to update this information unless required by law. CONTACT: Investor Contact Rob Dolski Chief Financial Officer rdolski@checkmatepharma.com Media Contact Karen Sharma MacDougall 781-235-3060 ksharma@macbiocom.com
India and neighbouring Bangladesh are struggling to cope with surging coronavirus cases, as South Korea restarts its use of the AstraZeneca vaccine.Authorities in India have blamed the ferocious resurgence of the virus mainly on crowding and a reluctance to wear masks.
BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a commercial-stage biotechnology company focused on developing and commercializing innovative medicines worldwide, today announced that clinical data on its anti-PD-1 antibody tislelizumab, in combination with the investigational spectrum-selective kinase inhibitor sitravatinib being jointly developed with Mirati Therapeutics, Inc. (Mirati), were presented in two oral presentations at the American Association for Cancer Research (AACR) Annual Meeting 2021. Data presented at the meeting were from two cohorts of a Phase 1b trial (NCT03666143), in patients with unresectable or metastatic melanoma who were refractory or resistant to PD-1/L1 inhibitors and in patients with advanced platinum-resistant ovarian cancer (PROC).
Cavani starred as United completed a second-half comeback against Tottenham
Jose Mourinho took aim at Ole Gunnar Solskjaer and the media in the wake of Tottenham’s 3-1 defeat to Manchester United, accusing journalists of lacking the “moral honesty” to treat him the same as other managers. Mourinho was irked by Solskjaer’s post-match claim that Tottenham’s Heung-min Son, who opened the scoring in controversial circumstances, tried to “con” United and “wouldn’t get any food” if he was his son. The South Korean’s 40th-minute strike came moments after Edinson Cavani had a goal ruled out by referee Chris Kavanagh, in consultation with the VAR, for a Scott McTominay foul on Son, who went down after being caught by the midfielder’s flailing hand.
It is highly unlikely the 94-year-old monarch will step down from royal duties
An early goal by Suat Serdar has put an end to Schalke's wretched 12-game run without a win in the Bundesliga and secured a 1-0 triumph over Augsburg."We're brutally happy that we can enjoy the feeling of victory.
The former United manager said Pogba should have been shown a red card after catching Serge Aurier
There's a chance that James Wiseman's rookie season could be over.
Yahoo Finance