0.36%	% of shares held by all insiders
92.33%	% of shares held by institutions
92.67%	% of float held by institutions
1,394	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Baillie Gifford and Company	16,743,103	30 Dec 2022	10.64%	3,385,455,426
Vanguard Group, Inc. (The)	12,836,349	29 Sept 2022	8.16%	2,449,047,025
Blackrock Inc.	11,783,746	29 Sept 2022	7.49%	2,248,220,899
Edgewood Management Company	7,427,083	29 Sept 2022	4.72%	1,417,013,165
State Street Corporation	6,569,010	29 Sept 2022	4.18%	1,253,301,417
Polen Capital Management, LLC	4,521,397	29 Sept 2022	2.87%	862,637,333
Bank Of New York Mellon Corporation	3,623,928	29 Sept 2022	2.30%	691,409,223
Loomis Sayles & Company, LP	3,598,290	29 Sept 2022	2.29%	686,517,749
Wellington Management Group, LLP	3,347,008	29 Sept 2022	2.13%	638,575,656
Morgan Stanley	3,184,547	29 Sept 2022	2.02%	607,579,722

Holder	Shares	Date reported	% out	Value
Vanguard Total Stock Market Index Fund	4,688,807	29 Sept 2022	2.98%	894,577,487
Advisors Inner Circle Fund-Edgewood Growth Fd	4,053,567	29 Sept 2022	2.58%	773,380,047
Vanguard International Growth Fund	3,890,075	29 Nov 2022	2.47%	848,347,556
Vanguard 500 Index Fund	3,561,247	29 Sept 2022	2.26%	679,450,315
Invesco ETF Tr-Invesco QQQ Tr, Series 1 ETF	2,098,412	30 Dec 2022	1.33%	424,298,906
Fidelity 500 Index Fund	1,723,555	30 Dec 2022	1.10%	348,502,821
SPDR S&P 500 ETF Trust	1,735,502	30 Dec 2022	1.10%	350,918,504
iShares Core S&P 500 ETF	1,412,502	30 Dec 2022	0.90%	285,607,904
Vanguard Specialized-Health Care Fund	1,377,704	30 Oct 2022	0.88%	315,246,229
iShares NASDAQ Biotechnology ETF	1,305,368	30 Dec 2022	0.83%	263,945,409

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