0.59%	% of shares held by all insiders
99.07%	% of shares held by institutions
99.66%	% of float held by institutions
960	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Price (T.Rowe) Associates Inc	39,270,192	30 Dec 2020	15.33%	2,860,048,083
Vanguard Group, Inc. (The)	27,548,047	30 Dec 2020	10.75%	2,006,324,263
FMR, LLC	26,439,111	30 Dec 2020	10.32%	1,925,560,454
Blackrock Inc.	21,062,113	30 Mar 2021	8.22%	1,566,599,964
Wellington Management Group, LLP	11,823,245	30 Dec 2020	4.61%	861,086,933
State Street Corporation	11,273,590	30 Dec 2020	4.40%	821,055,559
Geode Capital Management, LLC	5,468,005	30 Mar 2021	2.13%	406,710,211
Goldman Sachs Group, Inc.	3,402,532	30 Dec 2020	1.33%	247,806,405
Northern Trust Corporation	3,197,254	30 Mar 2021	1.25%	237,811,752
Parnassus Investments /ca	3,045,777	30 Mar 2021	1.19%	226,544,893

Holder	Shares	Date reported	% out	Value
Price (T.Rowe) Mid Cap Growth Fund	13,500,000	30 Dec 2020	5.27%	983,205,000
Vanguard Total Stock Market Index Fund	7,251,723	30 Dec 2020	2.83%	528,142,986
Vanguard Mid-Cap Index Fund	5,808,283	30 Dec 2020	2.27%	423,017,250
Vanguard 500 Index Fund	5,150,107	30 Dec 2020	2.01%	375,082,292
Fidelity Select Portfolios - Medical Technology & Devices Port	5,000,000	27 Feb 2021	1.95%	360,450,000
Parnassus Mid-Cap Fund	2,830,172	30 Dec 2020	1.10%	206,121,426
MassMutual Select Mid Cap Growth Fund	2,802,122	30 Dec 2020	1.09%	204,078,545
Fidelity Select Portfolios - Health Care	2,800,000	30 Mar 2021	1.09%	208,264,000
Price (T.Rowe) Institutional Mid-Cap Equity Growth Fund	2,792,000	30 Dec 2020	1.09%	203,341,360
Price (T.Rowe) Health Sciences Fund	2,745,451	30 Dec 2020	1.07%	199,951,196

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