1.18%	% of shares held by all insiders
10.51%	% of shares held by institutions
10.64%	% of float held by institutions
207	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Primecap Management Company	4,628,197	30 Dec 2020	1.92%	377,290,619
FMR, LLC	2,898,705	30 Dec 2020	1.20%	236,302,431
Price (T.Rowe) Associates Inc	1,574,821	30 Dec 2020	0.65%	128,379,407
Artisan Partners Limited Partnership	1,426,574	30 Dec 2020	0.59%	116,294,312
Bill & Melinda Gates Foundation	1,038,674	30 Dec 2020	0.43%	84,672,704
Artal Group S.A.	1,000,000	30 Dec 2020	0.42%	81,520,000
Blackrock Inc.	668,546	30 Dec 2020	0.28%	54,499,869
Susquehanna International Group, LLP	620,744	30 Dec 2020	0.26%	50,603,050
Redmile Group, LLC	580,746	30 Dec 2020	0.24%	47,342,413
Temasek Holdings (Private) Limited	537,634	30 Dec 2020	0.22%	43,827,923

Holder	Shares	Date reported	% out	Value
Vanguard Horizon Fund-Capital Opportunity Portfolio	2,028,836	29 Sep 2020	0.84%	140,456,316
Primecap Odyssey Aggressive Growth Fund	1,853,592	30 Dec 2020	0.77%	151,104,819
Price (T.Rowe) Health Sciences Fund	1,177,647	30 Dec 2020	0.49%	96,001,783
Fidelity Growth Company Fund	850,275	30 Dec 2020	0.35%	69,314,418
Artisan Mid-Cap Fund	771,584	29 Sep 2020	0.32%	53,416,760
iShares NASDAQ Biotechnology ETF	575,828	30 Dec 2020	0.24%	46,941,498
Columbia Fds Ser Tr I-Columbia Large Cap Growth Fd	339,885	30 Oct 2020	0.14%	29,012,583
Lord Abbett Bond-Debenture Fund	334,486	29 Sep 2020	0.14%	23,156,465
Fidelity Contrafund Inc	200,200	30 Dec 2020	0.08%	16,320,304
Fidelity Series Growth Company Fund	187,602	30 Dec 2020	0.08%	15,293,315

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