50.41%	% of shares held by all insiders
50.74%	% of shares held by institutions
102.32%	% of float held by institutions
121	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
QVT Financial LP	129,393,817	30 Sept 2022	18.37%	398,532,956
SB Investment Advisers (UK) LTD	99,375,586	30 Sept 2022	14.11%	306,076,804
Viking Global Investors, L.P.	88,238,700	30 Sept 2022	12.53%	271,775,196
Two Seas Capital LP	5,869,690	30 Sept 2022	0.83%	18,078,645
Blackrock Inc.	5,315,979	30 Sept 2022	0.75%	16,373,215
SC China Holding Ltd	5,205,418	30 Sept 2022	0.74%	16,032,687
Anchorage Capital Group, LLC	4,832,642	30 Sept 2022	0.69%	14,884,537
FMR, LLC	4,175,030	30 Sept 2022	0.59%	12,859,092
Adage Capital Partners GP L.L.C.	3,700,000	30 Sept 2022	0.53%	11,396,000
Woodline Partners LP	2,499,335	30 Sept 2022	0.35%	7,697,951

Holder	Shares	Date reported	% out	Value
Fidelity Growth Company Fund	7,031,255	30 Nov 2022	1.00%	33,046,898
Fidelity Select Portfolios - Biotechnology	5,957,525	30 Nov 2022	0.85%	28,000,367
iShares NASDAQ Biotechnology ETF	2,935,301	31 Dec 2022	0.42%	20,693,872
SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF	2,453,696	31 Dec 2022	0.35%	17,298,556
Fidelity Growth Company K6 Fund	2,094,738	30 Nov 2022	0.30%	9,845,268
Fidelity Series Growth Company Fund	2,030,300	30 Nov 2022	0.29%	9,542,410
Vanguard Extended Market Index Fund	1,362,029	30 Sept 2022	0.19%	4,195,049
Mutual Fund Ser Tr-Eventide Healthcare & Life Sciences Fund	990,300	30 Sept 2022	0.14%	3,050,124
Fidelity Extended Market Index Fund	520,440	30 Nov 2022	0.07%	2,446,068
Schwab Strategic Tr-Schwab U.S. Small Cap ETF	444,779	30 Nov 2022	0.06%	2,090,461

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