52.57%	% of shares held by all insiders
24.10%	% of shares held by institutions
50.81%	% of float held by institutions
181	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Baillie Gifford and Company	3,911,347	31 Mar 2022	2.09%	68,354,700
Blackrock Inc.	1,915,548	31 Mar 2022	1.02%	33,476,116
Bill & Melinda Gates Foundation	1,709,781	31 Mar 2022	0.91%	29,880,132
State Street Corporation	641,319	31 Mar 2022	0.34%	11,207,690
Millennium Management LLC	578,902	31 Mar 2022	0.31%	10,116,891
Norges Bank Investment Management	472,962	31 Dec 2021	0.25%	14,278,722
Price (T.Rowe) Associates Inc	450,642	31 Mar 2022	0.24%	7,875,419
Geode Capital Management, LLC	316,776	31 Mar 2022	0.17%	5,535,977
Citadel Advisors Llc	296,600	31 Mar 2022	0.16%	5,183,381
Susquehanna International Group, LLP	286,669	31 Mar 2022	0.15%	5,009,827

Holder	Shares	Date reported	% out	Value
Vanguard International Growth Fund	2,731,786	28 Feb 2022	1.46%	40,632,584
iShares NASDAQ Biotechnology ETF	422,730	30 Apr 2022	0.23%	6,839,771
Price (T.Rowe) Health Sciences Fund	335,860	31 Mar 2022	0.18%	5,869,489
Baillie Gifford International Growth Fund	233,787	31 Mar 2022	0.12%	4,085,661
Vanguard Variable Insurance Fund-International	214,039	31 Mar 2022	0.11%	3,740,545
iShares Russell Midcap Growth ETF	199,678	30 Apr 2022	0.11%	3,230,790
iShares Russell 1000 Growth ETF	172,290	30 Apr 2022	0.09%	2,787,652
iShares Russell Midcap ETF	146,651	30 Apr 2022	0.08%	2,372,813
Fidelity Mid Cap Index Fd	130,280	30 Apr 2022	0.07%	2,107,930
iShares Genomics Immunology and Healthcare ETF	120,651	30 Apr 2022	0.06%	1,952,133

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