Having only beaten Georgia in the last 12 months on top of this weekend’s opponents when they met in the Six Nations last February, Wales will hope to sign off the year on a high at the Parc y Scarlets to lift the spirits of a deeply concerned fan base.
Wayne Pivac’s side has suffered defeats against England, France, Ireland and Scotland this year, but Italy have not won any of the games they have played this calendar year, with their only victory coming in the 28-0 walkover that they received by virtue of Fiji being unable to play their Autumn Nations Cup group match last month.
Pivac has elected to experiment slightly with his side, with George North returning at the unfamiliar position of outside centre and both Callum Sheedy and Liam Williams preferred in place of Leigh Halfpenny and Dan Biggar respectively, while Italy boss Franco Smith hands Welsh-born Stephen Varney his first start.
Here’s everything you need to know about this weekend’s match.
When is it?
Wales vs Italy takes place on Saturday 5 December at Parc y Scarlets.
What time does it start?
The match kicks off at 4:45pm GMT.
How can I watch it?
Amazon Prime have bought the rights to the majority of the Autumn Nations Cup, with the paid subscription service set to show 14 of the 16 games throughout the tournament.
The match will be shown live on Amazon Prime from 3pm.
If you're not an Amazon Prime Video subscriber start a free 30-day trial here.
We may earn commission from some of the links in this article, but we never allow this to influence our content.
Is it on TV?
No. Channel 4 have the rights for Ireland’s three group games this autumn, with the two home matches shown exclusively and the trip to Twickenham to face England shared with Amazon Prime.
Highlights will be shown on Channel 4 at 7pm on Sunday 6 December.
Wales: Liam Williams; Josh Adams, George North, Johnny Williams, Louis Rees-Zammit; Callum Sheedy, Kieran Hardy; Nicky Smith, Sam Parry, Tomas Francis, Will Rowlands, Alun Wyn Jones, James Botham, Justin Tipuric, Taulupe Faletau.
Replacements: Elliot Dee, Wyn Jones, Leon Brown, Cory Hill, Aaron Wainwright, Gareth Davies, Ioan Lloyd, Jonah Holmes.
Italy: Jacopo Trulla; Luca Sperandio, Marco Zanon, Carlo Canna, Monty Ioane; Paolo Garbisi, Stephen Varney; Danilo Fischetti, Luca Bigi, Giosuè Zilocchi, Marco Lazzaroni, Niccolo Cannone, Maxime Mbanda, Johan Meyer, Braam Steyn.
Replacements: Leonardo Ghiraldini, Simone Ferrari, Pietro Ceccarelli, Cristian Stoian, Michele Lamaro, Guglielmo Palazzani, Tommaso Allan, Federico Mori.
Wales to win: 2/17
Italy to win: 9/1
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League. Terms: Min £10 Same Game Multi bet on any EPL match this Fri - Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.