The state's peak transport body is warning Tasmania could see its worst traffic ever today.
More than 300 Metro drivers are expected to strike for three hours from 6am as part of their 9 per cent wage claim.
The strike will affect up to 13,000 commuters and force more cars onto roads.
The entire police motorcycle fleet will patrol roads around Hobart.
Inspector Mark Beech-Jones says there will also be high-visibility cars in school zones.
"We are again reminding the public to take care around school zones, park correctly, obey the 40-kilometre speed limit but also realise there'll be a number of extra children that normally take a bus who will be either be walking, riding, or getting out of a vehicle in an unfamiliar area," he said.
The RACT's Vince Taskunas is urging motorists to leave home 30 minutes early to avoid heavy traffic.
"Take very good care of how close you are to the car in front of you because if we do have any small crashes on these commuter routes it will lead to substantial delays," he said.
Diane Ellison from the State School Parents and Friends group says the strike will affect some families more than others.
"We expect that there will be a number of students who won't make it, particularly those from outlying areas who perhaps have to catch two buses to get to school and their parents have got other obligations or are just not able to get them there themselves." She is also concerned about traffic hazards around schools during peak hour.
"The only options for children getting to school without the bus services it to be driven by car, or to walk if they're within walking distance, but that creates additional problems with safety with more children walking and more cars around schools," she said.
More action The Bus, Tram and Rail Union will also strike next Tuesday for two hours from 6pm.
Metro Tasmania is refusing to give ground, despite the threat of a prolonged industrial campaign.
Chief executive Heather Hazelgrove says it is disappointing but the state-owned company has no capacity to increase its offer from 6 per cent.
"We are not going to change our offer.
We believe the offer of 2 per cent for the next three years together with the wage compression is a very fair offer," she said.
Unions Tasmania chief Kevin Harkins has accused the company of inflaming the long-running pay dispute.
He says the company's pay offer is not acceptable.
"Holding the state to ransom really is what I see this company doing, not the workers," he said.
"They've got rights to exercise their industrial [position] and I think the company is being really, really, silly." Metro Tasmania says buses will be affected up until 11am.
The manager of one Hobart taxi company, Andrew Lovell says there will be extra taxis on the road but commuters should book ahead.
"People do call up on the spot and it's not something that we can't handle, but having you booking an hour in advance probably gives us an opportunity to make sure that we don't have delays."