Scleroderma Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Pipeline Comprising a Broad Spectrum of Molecular Targets

There are more than 50 companies that are developing therapies for the treatment of Scleroderma. Lenabasum (Corbus Pharmaceuticals) and Iloprost (Eicos Sciences) are in the most advanced stage (Phase III). Ongoing, Research and Development in the field of Scleroderma therapeutics are anticipated to bring a new effective therapy for the condition.

Los Angeles, USA, Sept. 22, 2021 (GLOBE NEWSWIRE) -- Scleroderma Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Pipeline Comprising a Broad Spectrum of Molecular Targets

There are more than 50 companies that are developing therapies for the treatment of Scleroderma. Lenabasum (Corbus Pharmaceuticals) and Iloprost (Eicos Sciences) are in the most advanced stage (Phase III). Ongoing, Research and Development in the field of Scleroderma therapeutics are anticipated to bring a new effective therapy for the condition.

DelveInsight’s ‘Scleroderma Pipeline Insights’ report lays down a holistic coverage of the available therapies, Scleroderma pipeline therapies in different developmental phases of clinical trials, key companies active in the Scleroderma pipeline domain, driving factors and restraints in the commercial launch of the Scleroderma pipeline therapies, and future trends.

Some of the key highlights from the Scleroderma Pipeline report:

• DelveInsight’s analysis depicts a robust Scleroderma Pipeline with 50+ active players in the domain working on 50+ pipeline therapies.

• Key Scleroderma pipeline therapies such as Lenabasum, EHP 101, FT011, Belumosudil, Guselkumab, ECCS 50, KHK4827, SAR156597, Treprostinil, HZN-825, GS-248, Brentuximab Vedotin, C21, ARG201, Belumosudil, CAM2043, Tofacitinib, Sarilumab, FCX 013, VIB7734, AVID200 and others are under evaluation in different phases of clinical trials for the treatment of Scleroderma.

• Corbus Pharmaceuticals, Emerald Health Pharmaceuticals, Gesynta Pharma, Formation Biologics, Fibrocell Science, CSL Behring, ChemomAb, Luminary Therapeutics, Certa Therapeutics, Kadmon Corporation, Janssen Pharmaceutical, Horizon Therapeutics, Acceleron Pharma, Tvardi Therapeutics, BriaCell Therapeutics, Blade Therapeutics, Biosplice Therapeutics, AnaMar, Immunemed, Viela Bio among several others are key prominent pharma companies working in the domain.

• In January 2021, Timber Pharmaceuticals received Orphan Drug Designation from U.S. FDA for TMB-003 for the Treatment of Systemic Sclerosis.

• CiVi 030 is an intravenous formulation of iloprost, a potent vasodilator and platelet inhibitor with anti-inflammatory and anti-fibrotic effects being developed for the treatment of digital ischemic episodes in people with Systemic Sclerosis (SSc). CiVi 030 received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for the treatment of Systemic Sclerosis (SSc).

• In April 2020, Horizon Therapeutics announced that it had acquired Curzion Pharmaceuticals and its development-stage oral selective lysophosphatidic acid 1 receptor (LPAR1) antagonist, CZN001 (renamed HZN-825), for the treatment of Systemic Sclerosis.

• FCX-013 is being developed as a disease-modifying, autologous cell-based gene therapy that utilizes lentiviral vectors to deliver functional matrix metalloproteinase 1 genes (MMP-1) to patients with moderate to severe localized Scleroderma.

• The U. S. Food and Drug Administration has granted Orphan Drug designation to FCX-013 for the treatment of localized Scleroderma. In addition, FCX-013 has been granted Rare Pediatric Disease designation and Fast Track designation for the treatment of moderate to severe localized Scleroderma.

Request for Sample to know which pharma company is expected to be at the forefront in the coming years @ Scleroderma Emerging Therapies and Forecast

The Scleroderma Pipeline report comprises detailed information on ongoing clinical trials, deals, mergers & acquisitions taking place in the domain, recent approvals and failures in space, and growth prospects across the Scleroderma domain.

Scleroderma Overview

Scleroderma is a group of rare diseases that leads to the hardening and tightening of the skin and connective tissues. There are 2 major types of Scleroderma: Localized Scleroderma that affects the skin and Systemic Scleroderma that affects blood circulation and internal organs as well as the skin. The condition appears to affect women more as compared to men. At present, there exists no cure for the disease; however, there are symptomatic treatment approaches available.

Discover more about the disease, treatments, and pipeline therapies @ Scleroderma Pipeline Assessment

Scleroderma Pipeline Drugs

Drug	Company	Phase	MoA	RoA
Lenabasum	Corbus Pharmaceuticals	III	Cannabinoid receptor CB2 agonists	Oral
Iloprost	Eicos Sciences	III	Epoprostenol agonists	Intravenous
KHK4827	Kyowa Kirin	III	Interleukin 17 receptor antagonists	Subcutaneous
ECCS-50	Cytori therapeutics	III	Cell replacements	Subcutaneous
EHP 101	Emerald Health Pharmaceuticals	II	Cannabinoid receptor CB2 agonists; Endothelial PAS domain-containing protein 1 inhibitors; Hypoxia-inducible factor 1 inhibitors; Peroxisome proliferator-activated receptor-gamma agonists	Oral
FT011	Certa Therapeutics	II	Platelet-derived growth factor inhibitors	Oral
Belumosudil	Kadmon Corporation	II	Rho-associated kinase inhibitors	Oral
Guselkumab	Janssen Pharmaceutical	II	Interleukin-23 subunit p19 inhibitors	Intravenous, Subcutaneous
FCX 013	Castle Creek Biosciences	I/II	Gene transference; Matrix metalloproteinase 1 replacements	Intradermal
VIB7734	Viela Bio	I	Dendritic cell inhibitors	NA
CM-101	Chemomab Therapeutics	I	Chemokine CCL24 inhibitors	Intravenous
AM1476	AnaMar	I	Serotonin 2B receptor antagonists	Oral
LMY-920	Luminary Therapeutics	Preclinical	Immunologic cytotoxicity; T lymphocyte replacements	Parenteral
CAN-10	Cantargia	Preclinical	Interleukin 1 inhibitors; Interleukin-33 inhibitors	NA
hzVSF v13	ImmuneMed	Discovery	Immunomodulators; Virus replication inhibitors	NA

Request for Sample to know more @ Scleroderma Pipeline Analysis, Key Companies, and Futuristic Trends

Scleroderma Therapeutics Assessment

The Scleroderma Pipeline report proffers an integral view of the Scleroderma emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.

By Product Type

• Mono

• Combination

By Stage

• Discovery

• Pre-clinical

• Phase I

• Phase II

• Phase III

By Molecule Type

• Monoclonal Antibody

• Peptides

• Polymer

• Small molecule

• Gene therapy

By Route of Administration

• Oral

• Parenteral

• Subcutaneous

• Intravenous

• Intradermal

• Topical

By Mechanism of Action

• Collagen inhibitors; Cytokine inhibitors

• Dendritic cell inhibitors

• Serotonin 2B receptor antagonists

• Chemokine CCL24 inhibitors

• Platelet-derived growth factor inhibitors

• Gene transference; Matrix metalloproteinase 1 replacement

• Cell replacements

• Interleukin 1 inhibitors; Interleukin-33 inhibitors

By Targets

• Proteins

• Replication pathways

For rich insights into emerging therapies and assessment, visit Scleroderma Pipeline Emerging Novel Therapies

Scope of the Scleroderma Drug Pipeline Report

Coverage: Global
Key Players: Corbus Pharmaceuticals, Emerald Health Pharmaceuticals, Gesynta Pharma, Formation Biologics, Fibrocell Science, CSL Behring, ChemomAb, Luminary Therapeutics, Certa Therapeutics, Kadmon Corporation, Janssen Pharmaceutical, Horizon Therapeutics, Acceleron Pharma, Tvardi Therapeutics, BriaCell Therapeutics, Blade Therapeutics, Biosplice Therapeutics, AnaMar, Immunemed, Viela Bio among others.
Key Scleroderma Pipeline Therapies: Lenabasum, EHP 101, FT011, Belumosudil, Guselkumab, ECCS 50, KHK4827, SAR156597, Treprostinil, HZN-825, GS-248, Brentuximab Vedotin, C21, ARG201, Belumosudil, CAM2043, Tofacitinib, Sarilumab, FCX 013, VIB7734, AVID200 and several others.

Discover more about the scope of the report @ Scleroderma Emerging Therapies, Treatments, and Ongoing Clinical Trials

Table of Contents

1	Report Introduction
2	Executive Summary
3	Scleroderma Disease Overview
4	Scleroderma Pipeline Therapeutics Comparative Analysis
5	Scleroderma Therapeutic Assessment
6	In-depth Commercial Assessment
7	Scleroderma – DelveInsight’s Analytical Perspective
8	In-depth Commercial Scleroderma Assessment
9	Scleroderma Collaboration Deals
10	Late Stage Scleroderma Products (Phase III)
10.1	Lenabasum: Corbus Pharmaceuticals
11	Mid-Stage Scleroderma Products (Phase II)
11.1	EHP 101: Emerald Health Pharmaceuticals
12	Early Stage Scleroderma Products (Phase I)
12.1	VIB7734: Viela Bio
13	Pre-clinical and Discovery Stage Scleroderma Products
13.1	LMY-920: Luminary Therapeutics
14	Inactive Scleroderma Pipeline Products
15	Key Scleroderma Products
16	Unmet Needs
17	Scleroderma Market Drivers and Barriers
18	Future Perspectives and Conclusion
19	Analyst Views
20	Key Scleroderma Companies
21	Appendix

Learn more about the report offerings @ Scleroderma Pipeline Therapies and Emerging Trends

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