United meet Liverpool for the second time in seven days after securing a goalless Premier League draw at Anfield last weekend. The Red Devils went on to win 2-1 at Fulham in midweek to retake top spot in the table, while Liverpool are six points off the pace following Thursday night's shock 1-0 home loss to Burnley.
Solskjaer has plenty of experience of success at United: he won six League titles as a player along with two FA Cups and the Champions League, though he has lost four semi-finals so far as manager.
The Norwegian scored a memorable late winner in an FA Cup fourth-round tie against Liverpool on January 24, 1999 - a result which helped United build momentum en route to a remarkable Treble triumph.
Solskjaer is hoping that his experience that day will serve him well in the same fixture 22 years to the day on Sunday - though knows such games are based on "very fine margins".
"Of course we can transform a few things from that season," he said. "We know that there's tight moments, very fine margins.
"We know in that season we were close to going out against Liverpool. Peter Schmeichel saved a penalty from Dennis Bergkamp in the semi-final in injury time.
"Those moments, I think they gave us the mental advantage, especially in the semi-final.
"But against Liverpool as well in that fourth round, when you get that boost of turning 1-0 down to a 2-1 win against a big team, it's massive.
"The FA Cup is a run we've got to enjoy as long as it lasts. We got to the semis last year and as I said, we're going to make a few changes but we'll put a team out there that I hope can go through."
Additional reporting by PA.