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Juventus have kept alive their Champions League qualification hopes by beating Serie A champions Inter Milan 3-2, while Atalanta have again clinched a place in Europe's premier competition.
Juan Cuadrado scored twice for Juventus on Saturday, converting a clinching penalty kick in the 88th minute as they rose to fourth ahead of their final game at Bologna next weekend.
Atalanta consolidated their second place in the Italian league by beating Genoa 4-3, a win that ensures they can no longer finish outside the top four.
Napoli, two points behind Juventus, still have two games left and the Turin giants will be hoping for a favour from Fiorentina, who host Napoli on Sunday.
In the day's late game, Roma defeated city rivals Lazio 2-0 in their derby with goals from Henrikh Mkhitaryan and Pedro. Lazio defender Francesco Acerbi was sent off late.
Atalanta's qualification for the Champions League for the third consecutive year, despite a much smaller budget than their illustrious rivals, was a remarkable achievement.
Duvan Zapata got the visitors off to a fine start in the ninth minute before setting up Ruslan Malinovskyi in the 26th. Robin Gosens then made it 3-0 before halftime.
Eldor Shomurodov pulled one back for Genoa, followed three minutes later by Mario Pasalic restoring Atalanta's three-goal lead.
Gosens conceded a penalty for handball - converted by Goran Pandev in the 67th - and Shomurodov's second goal in the 84th ensured a nervy finale, but Atalanta held on.
Antonio Conte's Inter had already ended Juve's record run of nine straight Serie A titles, but they couldn't sink his former team's chances of reaching the Champions League.
Referee Gianpaolo Calvarese had a busy game, awarding three penalties and relying on VAR for assistance.
But there was no VAR check for the deciding penalty late on - awarded when Cuadrado fell after running into the retreating Ivan Perisic.
The first spot kick was awarded to Juventus through VAR, which showed Matteo Darmian holding back Giorgio Chiellini with his arm.
Cristiano Ronaldo took his second chance from the rebound in the 24th after a poor spot kick.
Inter equalised through another penalty, converted by Romelu Lukaku in the 35th, after Calvarese checked video replays that showed Lautaro Martinez falling under Matthijs de Ligt's contact.
Cuadrado restored Juve's lead with a deflected shot before the break.
Inter were given a boost in the 55th when Juve's Rodrigo Bentancur was sent off for his second yellow card for a foul on Lukaku.
Martinez thought he equalised with a spectacular overhead kick but the goal was ruled out for an apparent foul on the wily Chiellini even though TV replays showed there was minimal contact from Lukaku.
Chiellini was again in the spotlight when he bundled the ball into his own net under pressure from Lukaku in the 83rd.
Both sides finished with 10 men when Marcelo Brozovic was sent off with his second yellow card in injury time.