Holden thinks it will achieve job cuts in Adelaide without any forced redundancies.
It is cutting its workforce by 170, blaming a strong Australian dollar for slowing sales.
Holden corporate affairs manager Sean Poppitt said the company was confident enough workers would take up voluntary separation packages.
"Decisions like this are never easy to make, but it is reassuring that once we made this difficult decision that we were able to work with the unions and with our employees and give people options for their future, so we're happy that once we had to make the decision it's be dealt with very humanely and very professionally across the board," he said.
Those workers going are expected to work their final shifts on December 14.