The tech giant has postponed reopening offices for most workers until mid-October and is rolling out a policy of compulsory vaccinations at its sprawling campuses.
In an email to more than 130,000 staff members, chief executive Sundar Pichai said employees arriving at work in the US would be required to be vaccinated.
The policy will then be expanded to other countries such as the UK, where the company employs some 5,000 people.
Mr Pichai told staff: “Getting vaccinated is one of the most important ways to keep ourselves and our communities healthy in the months ahead.”
He said there would be exemptions for those who could not be vaccinated for medical or other reasons and the worldwide policy would depend on local regulations and access.
Return to work protocols were agreed by Hollywood unions and major studios last week and give producers the option to “implement mandatory vaccination policies for casts and crew on a production-by-production basis”.
It comes as Google pushed back the date it would demand staff return to offices amid concern over the highly infectious Delta variant.
Google had asked staff to start coming back to their desks from September, but will now require it from October 18.
Google, along with other tech giants Apple and Amazon, have said they expect the majority of staff will work from an office when the pandemic subsides.
Google is the first of the large tech company to make vaccination compulsory.
In the UK, Bank of America, Bloomsbury and Pimlico Plumbers have all told staff they are expected to be jabbed before returning to work.
Facebook has also said it would also require workers to be vaccinated to return to its US office, according to the Financial Times.