There are to be 75 jobs cut from the head office of agribusiness Elders in Adelaide.
A statement to the Australian Stock Exchange says the cuts to back room operations will reduce the costs of corporate operations without affecting the retail network.
Elders chief executive Malcolm Jackman blamed market conditions and divestment in recent years of non-core businesses.
"It's very sombre today so I think on days like today experience in history tells you it's really bad for the people that lost their jobs today and then tomorrow it'll be really bad for the people that are staying and everybody gets to terms with the fact that people they've known, they've worked with won't be working with them in the future," he said.
The company said the changes would be implemented by the end of September.
Elders' board will also be reduced in size with the voluntary retirements of two members, Ray Grigg and Anna Buduls.
Meat jobs gone Another 75 South Australian workers are out of a job because of the closure of a kangaroo meat export plant in Adelaide's northern suburbs.
Macro Meats suspended its operations at Dry Creek last week.
General manager Doug Jobson said the industry had been struggling because of a downturn in exports.
"We will need to see some significant changes in the current market to see a reinstatement of these people," he said.
Ray Borda of the Kangaroo Industries Association said the export market was on the verge of collapse.
"There were 16 game meat export plants in Australia and now there's three or four that are left," he said.
He urged the Federal Government to do more to allow resumption of exports to Russia, which banned kangaroo meat imports three years ago.
The Government said it supported the kangaroo meat trade but the industry needed to meet international trading standards.