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Lead clinical-stage oral progesterone receptor (PR) antagonist ONA-XR demonstrates monotherapy clinical activity in advanced granulosa cell tumor of the ovary
Trial advanced to second stage to evaluate combination of ONA-XR with oral antiestrogen
PHILADELPHIA, May 05, 2022 (GLOBE NEWSWIRE) -- Context Therapeutics Inc. (“Context” or the “Company”) (Nasdaq: CNTX), a women’s oncology company developing small molecule and immunotherapy treatments for breast and gynecological cancers, today announced that an abstract on the results of the monotherapy portion of its ongoing Phase 2 trial of lead candidate onapristone extended release (ONA-XR) in granulosa cell tumors of the ovary was accepted for oral presentation at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting taking place June 3-7, 2022, at the McCormick Place Convention Center in Chicago, IL.
“We are thrilled that ASCO has recognized the potential of our novel clinical program for ONA-XR, a potent, specific progesterone receptor (PR) antagonist, in the treatment of granulosa cell tumors (GCTs) of the ovary,” said Martin Lehr, CEO of Context Therapeutics. “GCTs are a rare form of ovarian cancer that is highly enriched for the target of ONA-XR. We look forward to sharing the stage I monotherapy data at the conference and continuing enrollment of the stage II portion evaluating the combination of ONA-XR plus the antiestrogen anastrozole.”
Title: Basket study of oral progesterone antagonist onapristone extended release (ONA-XR) in progesterone receptor positive (PR+) recurrent granulosa cell (GCT), low-grade serous carcinoma ovarian (LGSOC), or endometrioid endometrial cancer (EEC)
Session Type/Title: Poster Discussion Session, Gynecologic Cancer
Session Date and Time: Saturday, June 4, 2022; 1:15 PM - 4:15 PM CDT
Abstract Number: 5521
Presenter: Rachel Grisham, M.D., Memorial Sloan-Kettering Cancer Center
For more information, visit the ASCO Annual Meeting website.
About Context Therapeutics®
Context Therapeutics Inc. (Nasdaq: CNTX), is a women’s oncology company developing small molecule and immunotherapy treatments to transform care for breast and gynecological cancers. The Company’s robust clinical program for lead candidate onapristone extended release (ONA-XR) comprises three Phase 2 clinical trials and one Phase 1b/2 clinical trial in hormone-driven breast, ovarian, and endometrial cancer. ONA-XR is a novel, first-in-class small molecule under development as a potent and specific antagonist of the progesterone receptor, a key unchecked mechanism in hormone-driven women’s cancers. Context is headquartered in Philadelphia, PA. For more information, visit www.contexttherapeutics.com.
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