Asian equities have followed Wall Street sharply lower and bonds have rallied as risk sentiment sours amid growing worries that inflation may persist even after global growth has peaked.
Japan's Nikkei tumbled 1.86 per cent on Friday, while the broader Topix slid 1.95 per cent.
Australian stocks slumped 2.05 per cent and South Korea's Kospi lost 1.51 per cent, while an MSCI index of Asia-Pacific stocks dropped 1.07 per cent.
Chinese markets are closed for a week from Friday for the Golden Week holiday.
"You can argue whether it's really stagflation or not, but the whole growth-inflation backdrop seems to have just tilted to a less favourable one," said Rob Carnell, Asia-Pacific head of research at ING in Singapore.
"Whether or not this is actually going to get imbedded and create problems for years to come, we don't need to know right now - it's sufficiently scary that what we're seeing in markets is justified."
US stock futures pointed to a 0.51 per cent decline for the S&P 500 following a 1.19 per cent drop in the index overnight.
Nasdaq futures also signalled a 0.49 per cent retreat, adding to Thursday's 0.43 per cent loss.
The benchmark 10-year Treasury note continued to rally in Tokyo trading, with the yield sliding to the lowest since September 28 at 1.48 per cent.
The dollar index, which measures the currency against six major rivals, was off Thursday's one-year high of 94.504, last changing hands at 94.326.
Federal Reserve chair Jerome Powell said on Wednesday that resolving "tension" between high inflation and high unemployment is the Fed's most urgent issue, acknowledging a potential conflict between the US central bank's two goals of stable prices and full employment.
China has proved a particular worry for investors, hit by regulatory curbs in the tech and property sectors, and now grappling with a power shortage that threatens to push up energy prices globally.
Crude prices continued to ease on Friday after Brent topped $US80 a barrel earlier in the week for the first time in three years.
Brent crude futures were largely flat compared to Thursday at $US78.32, while US crude futures were also little changed at $US75.07.
Gold, an inflation hedge and safe haven, edged back 0.1 per cent to $US1,755.35 an ounce, following Thursday's 1.77 per cent surge, the biggest since March.