| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 1-Jan-10 | SNUTCH TERRANCE P.
Officer | 23,809 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | SNUTCH TERRANCE P.
Officer | 315,852 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | GALLEN CHRISTOPHER C.
Officer | 978,291 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | RICHARDSON HARTLEY T
Director | 3,137,569 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | RICHARDSON HARTLEY T
Director | 30,111 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | HUNTER WILLIAM L
Director | 30,111 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | CORRIGAN MARK
Director | 30,111 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jan-10 | MPM BIOVENTURES III LLC
Beneficial Owner (10% or more) | 7,913,653 | Disposition (Non Open Market) | N/A | | 1-Jan-10 | EVNIN LUKE
Beneficial Owner (10% or more) | 7,913,653 | Disposition (Non Open Market) | N/A | | 22-Dec-09 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 3,177,899 | Sale at $0.80 per share. | $2,542,319 | | 21-Dec-09 | FOLEY TODD
Director | N/A | Statement of Ownership | N/A | | 21-Dec-09 | WRIGHT C. EUGENE
Officer | N/A | Statement of Ownership | N/A | | 21-Dec-09 | SNUTCH TERRANCE P.
Officer | 53,982 | Statement of Ownership | N/A | | 21-Dec-09 | SNUTCH TERRANCE P.
Officer | 716,114 | Statement of Ownership | N/A | | 21-Dec-09 | GALLEN CHRISTOPHER C.
Officer | 2,218,024 | Statement of Ownership | N/A | | 21-Dec-09 | RICHARDSON HARTLEY T
Director | 9,564,403 | Statement of Ownership | N/A | | 21-Dec-09 | RICHARDSON HARTLEY T
Director | 68,268 | Statement of Ownership | N/A | | 21-Dec-09 | CORRIGAN MARK
Director | 68,268 | Statement of Ownership | N/A | | 21-Dec-09 | MPM BIOVENTURES III LLC
Beneficial Owner (10% or more) | 22,547,613 | Statement of Ownership | N/A | | 21-Dec-09 | EVNIN LUKE
Beneficial Owner (10% or more) | 22,547,613 | Statement of Ownership | N/A | | 21-Dec-09 | HUNTER WILLIAM L
Director | 68,268 | Statement of Ownership | N/A | | 26-Jan-09 | COLE JASON
Officer | 2,633 | Automatic Sale at $0.63 per share. | $1,658 | | 26-Jan-09 | BORISY ALEXIS
Officer | 5,256 | Automatic Sale at $0.63 per share. | $3,311 | | 26-Jan-09 | FORRESTER ROBERT
Officer | 2,632 | Automatic Sale at $0.63 per share. | $1,658 | | 5-Dec-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 1,530,572 | Purchase at $0.57 per share. | $872,426 | | 4-Dec-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 10,300 | Purchase at $0.55 per share. | $5,665 | | 3-Dec-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 13,400 | Purchase at $0.54 per share. | $7,236 | | 2-Dec-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 9,800 | Purchase at $0.55 per share. | $5,390 | | 1-Dec-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 26,800 | Purchase at $0.55 per share. | $14,740 | | 26-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 6,600 | Purchase at $0.49 per share. | $3,234 | | 25-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 12,300 | Purchase at $0.47 per share. | $5,781 | | 24-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 83,100 | Purchase at $0.45 per share. | $37,395 | | 21-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 12,000 | Purchase at $0.45 per share. | $5,400 | | 14-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 9,200 | Purchase at $0.60 per share. | $5,520 | | 13-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 9,000 | Purchase at $0.60 per share. | $5,400 | | 12-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 3,600 | Purchase at $0.60 per share. | $2,160 | | 11-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 139,100 | Purchase at $0.60 per share. | $83,460 | | 10-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 14,000 | Purchase at $0.58 per share. | $8,119 | | 7-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 109,700 | Purchase at $0.58 per share. | $63,625 | | 6-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 11,200 | Purchase at $0.59 per share. | $6,608 | | 5-Nov-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 180,400 | Purchase at $0.60 per share. | $108,240 | | 16-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 2,031,000 | Purchase at $0.65 per share. | $1,320,150 | | 15-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 712,000 | Purchase at $0.65 per share. | $462,800 | | 13-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 25,500 | Purchase at $0.65 per share. | $16,575 | | 10-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 58,300 | Purchase at $0.60 per share. | $34,980 | | 8-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 103,100 | Purchase at $0.62 per share. | $63,922 | | 7-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 790,000 | Purchase at $0.66 per share. | $521,400 | | 6-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 4,107,899 | Statement of Ownership | N/A | | 6-Oct-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 2,429,000 | Statement of Ownership | N/A | | 24-Apr-08 | BAIRD LYNN G
Officer | 1,588 | Disposition (Non Open Market) at $3.58 per share. | $5,685 | | 26-Jan-08 | GRAU DANIEL
Officer | 15,875 | Disposition (Non Open Market) at $5.15 per share. | $81,756 | | 26-Jan-08 | BORISY ALEXIS
Officer | 3,969 | Disposition (Non Open Market) at $5.15 per share. | $20,440 | | 26-Jan-08 | KEITH CURTIS T
Officer | 2,372 | Disposition (Non Open Market) at $5.15 per share. | $12,215 | | 26-Jan-08 | FORRESTER ROBERT
Officer | 1,985 | Disposition (Non Open Market) at $5.15 per share. | $10,222 |
|
* = Where indicated, some values are estimates.
1 = Potential proceeds estimated by the filer.
2 = Estimated based on the average of multiple prices reported.
3 = Multiple dates reported. Most recent date shown. |
|
0.06 (4.83%) 
Insider Trans.
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