| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 9-Dec-09 | FIRST EAGLE VALUE IN BIOTECHNOLOGY MASTER FUND, LT Beneficial Owner (10% or more) | 5,153,517 | Disposition (Non Open Market) at $0 per share. | N/A | | 9-Dec-09 | FIRST EAGLE VALUE IN BIOTECHNOLOGY MASTER FUND, LT Beneficial Owner (10% or more) | 5,153,517 | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-09 | PECOTA NANCY E Officer | 200,000 | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-09 | GRIMES D JEFFERY Officer | 200,000 | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-09 | GONDA IGOR Officer | 1,000,000 | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-May-09 | THOMPSON VIRGIL Director | 156,250 | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-May-09 | SIEBERT JOHN M Director | 93,750 | Acquisition (Non Open Market) at $0 per share. | N/A | | 15-May-09 | BARKER FRANK H Director | 93,750 | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | FIRST EAGLE VALUE IN BIOTECHNOLOGY MASTER FUND, LT Beneficial Owner (10% or more) | 23,765,381 | Statement of Ownership | N/A | | 23-Feb-09 | FIRST EAGLE VALUE IN BIOTECHNOLOGY MASTER FUND, LT Beneficial Owner (10% or more) | 14,298,624 | Statement of Ownership | N/A | | 21-Jan-09 | PECOTA NANCY E Officer | 35,000 | Acquisition (Non Open Market) | N/A | | 21-Jan-09 | GRIMES D JEFFERY Officer | 35,000 | Acquisition (Non Open Market) | N/A | | 21-Jan-09 | GONDA IGOR Officer | 80,000 | Acquisition (Non Open Market) | N/A | | 29-Oct-08 | RA CAPITAL MANAGEMENT, LLC Beneficial Owner (10% or more) | 5,600,000 | Sale at $0.25 per share. | $1,400,000 | | 21-Oct-08 | TANG KEVIN C Beneficial Owner (10% or more) | 10,000 | Purchase at $0.24 per share. | $2,400 | | 20-Oct-08 | TANG KEVIN C Beneficial Owner (10% or more) | 17,000 | Purchase at $0.24 per share. | $4,080 | | 13-Oct-08 | TANG KEVIN C Beneficial Owner (10% or more) | 25,000 | Purchase at $0.24 per share. | $6,000 | | 10-Oct-08 | TANG KEVIN C Beneficial Owner (10% or more) | 45,000 | Purchase at $0.24 per share. | $10,800 | | 6-Oct-08 | RA CAPITAL MANAGEMENT, LLC Beneficial Owner (10% or more) | 1,000,000 | Sale at $0.35 per share. | $350,000 | | 22-Sep-08 | PECOTA NANCY E Officer | N/A | Statement of Ownership | N/A | | 15-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 5,310,000 | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jul-08 | LYNCH TIMOTHY P Director | 240,000 | Acquisition (Non Open Market) at $0.80 per share. | $192,000 | | 1-Jul-08 | GRIMES D JEFFERY Officer | 45,893 | Statement of Ownership | N/A | | 5-Jun-08 | GONDA IGOR Officer | 15,000 | Purchase at $0.75 per share. | $11,250 | | 4-Apr-08 | BARKER FRANK H Director | 5,000 | Purchase at $1.05 per share. | $5,250 | | 3-Apr-08 | BARKER FRANK H Director | 15,000 | Purchase at $1.05 per share. | $15,750 | | 2-Apr-08 | BARKER FRANK H Director | 20,000 | Purchase at $1.05 per share. | $21,000 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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